Is Tri-Luma (fluocinolone acetonide, hydroquinone, and tretinoin) available in a generic form?

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Last updated: July 3, 2025View editorial policy

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From the Research

Yes, Tri-Luma (fluocinolone acetonide, hydroquinone, and tretinoin) is available in a generic form, as evidenced by a recent study 1 that compared the efficacy and safety of a generic formulation with the brand-name product, TRI-LUMA.

Key Points to Consider

  • The generic formulation of fluocinolone acetonide, hydroquinone, and tretinoin cream has been shown to be as effective as TRI-LUMA in treating moderate-to-severe melasma in Chinese patients 1.
  • The study found no significant difference in the incidence of adverse effects between the generic and brand-name formulations 1.
  • The availability of a generic formulation may provide a more affordable treatment option for patients with melasma, as the brand-name product can be expensive and may have varying insurance coverage.
  • However, it is essential to note that the generic formulation may not be widely available, and patients should consult with their healthcare provider to determine the best treatment option for their specific condition.

Important Considerations

  • The study 1 was conducted in Chinese patients, and the results may not be generalizable to other populations.
  • The generic formulation may have a different safety profile or efficacy in patients with different skin types or conditions.
  • Patients should discuss the potential benefits and risks of the generic formulation with their healthcare provider to determine the best course of treatment.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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