What is the next medication to try if ondansetron (Zofran) is not effective for vomiting?

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From the Guidelines

If ondansetron (Zofran) is not effective for vomiting, the next medication to try would typically be aprepitant, which has been shown to be effective in preventing nausea and vomiting in patients receiving highly and moderately emetogenic chemotherapy 1.

Mechanism of Action

Aprepitant works by selectively blocking the binding of substance P at the NK-1 receptor in the central nervous system, providing a different and complementary mechanism of action to other antiemetics.

Efficacy

Studies have shown that aprepitant, in combination with ondansetron and dexamethasone, is more effective than the two-drug regimen alone in controlling both acute and delayed emesis in patients receiving emetogenic chemotherapy 1.

Dosage

The recommended dosage of aprepitant is 125 mg orally on day 1, followed by 80 mg orally on days 2 and 3, in combination with a 5-HT3 receptor antagonist and dexamethasone.

Considerations

It's essential to consider the underlying cause of vomiting when selecting the next agent, as certain conditions may respond better to specific medications. Also, be aware that aprepitant may interact with other medications, such as corticosteroids, and the dose of oral/i.v. corticosteroids should be reduced to 50%/75% when combined with aprepitant 1.

Alternative Options

Other options, such as palonosetron, may also be considered, especially if aprepitant is not available or not suitable for the patient 1.

Key Points

  • Aprepitant is a effective option for preventing nausea and vomiting in patients receiving highly and moderately emetogenic chemotherapy.
  • Aprepitant works by blocking the NK-1 receptor in the central nervous system.
  • The recommended dosage of aprepitant is 125 mg orally on day 1, followed by 80 mg orally on days 2 and 3.
  • Aprepitant may interact with other medications, such as corticosteroids.

From the FDA Drug Label

Δ Difference (%): Aprepitant 40 mg minus Ondansetron. * Estimated odds ratio for Aprepitant versus Ondansetron. A value of >1 favors Aprepitant over Ondansetron. Treatment n/m (%)Aprepitant vs Ondansetron ΔOdds ratio*Analysis Primary Endpoints No Vomiting 0 to 24 hours (Superiority)(no emetic episodes) Aprepitant 40 mg246/293 (84.0)12.6%2.1P<0.001† Ondansetron200/280 (71. 4)

The next medication to try if ondansetron (Zofran) is not effective for vomiting is Aprepitant (40 mg), as it has shown to be effective in preventing vomiting in patients who have not responded to ondansetron, with a 12.6% improvement over ondansetron in the 0 to 24 hours following the end of surgery 2.

From the Research

Next Line of Treatment for Vomiting

If ondansetron (Zofran) is not effective for vomiting, the next medication to consider is:

  • Aprepitant (Emend), a neurokinin-1 (NK(1)) receptor antagonist, which has been shown to alleviate the emetic effects of substance P 3, 4, 5, 6

Dosage and Administration

The recommended dosage of aprepitant is:

  • 125 mg on day 1, followed by 80 mg once daily on days 2 and 3, when combined with a standard regimen of a corticosteroid (dexamethasone) and a serotonin 5-HT(3) receptor antagonist (ondansetron) 3, 4

Efficacy and Safety

Aprepitant has been shown to be effective in preventing acute and delayed chemotherapy-induced nausea and vomiting (CINV) associated with highly emetogenic chemotherapy (HEC) and moderately emetogenic chemotherapy (MEC) 3, 4, 5 The addition of aprepitant to a standard regimen of intravenous ondansetron and oral dexamethasone has been shown to reduce chemotherapy-induced nausea and vomiting and is generally well tolerated 4, 6

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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