From the Guidelines
NAD infusion is not a recommended treatment for any medical condition due to limited clinical evidence supporting its efficacy and safety. The primary function of NAD, a coenzyme derived from niacin, is to catalyze reactions in the body, with over 400 enzymes requiring it for various metabolic processes, including energy production, cholesterol and fat creation, DNA repair, and antioxidant effects 1. Niacin, the precursor to NAD, can be obtained through the diet or synthesized from the amino acid tryptophan in the liver, with a recommended daily intake of 40 mg/day in parenteral nutrition 1.
Some of the key points to consider when evaluating NAD infusion include:
- Limited clinical evidence supporting its use as a medical treatment
- Potential side effects, such as flushing, headache, nausea, and chest discomfort during infusion
- Unknown long-term effects
- High cost, typically ranging from $300-1000 per session
- Lack of FDA approval for any specific medical condition
Given the current state of evidence, it is essential to exercise caution when considering NAD infusion, and consultation with a healthcare provider is crucial before undergoing such treatment. The focus should be on established, evidence-based treatments that prioritize morbidity, mortality, and quality of life, rather than unproven and potentially costly interventions like NAD infusion 1.
From the Research
Purpose of NAD Infusion
The purpose of NAD (Nicotinamide adenine dinucleotide) infusion is to increase NAD levels in the body, which can help to improve various health conditions. Some of the potential benefits of NAD infusion include:
- Improving energy metabolism and reducing fatigue 2, 3
- Enhancing insulin sensitivity and glucose metabolism 2, 3
- Reducing anxiety and depression 3, 4
- Improving cognitive function and reducing the risk of age-related diseases 5, 6
- Treating substance use disorder (SUD) and reducing cravings 4
Clinical Evidence
Several studies have investigated the clinical evidence for targeting NAD therapeutically. These studies have shown that NAD infusion can be safe and effective in improving various health conditions, including:
- Chronic fatigue syndrome (CFS) 3
- Metabolic disorders, such as diabetes and fatty liver disease 2, 3
- Neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease 3, 5
- Substance use disorder (SUD) 4
Mechanism of Action
NAD infusion works by increasing the levels of NAD in the body, which can help to improve energy metabolism, reduce oxidative stress, and enhance cellular function. NAD is a coenzyme that plays a critical role in various cellular processes, including: