From the Research
Leucovorin (folinic acid) should be used immediately after opening the vial, and any unused portion should be discarded. Once reconstituted, leucovorin solution is typically stable for only 24 hours when refrigerated at 2-8°C (36-46°F) 1. The stability of opened vials varies by manufacturer and formulation, so always check the specific product information. Leucovorin is sensitive to light and can degrade when exposed to air and light, potentially reducing its efficacy. This degradation occurs because leucovorin is a reduced folate that can oxidize when exposed to environmental factors. For patient safety, it's essential to follow aseptic technique when handling the medication, and if the solution appears discolored or contains particles, it should not be used. If you need to store reconstituted leucovorin, keep it in the refrigerator in a light-resistant container, clearly labeled with the date and time of reconstitution to ensure it's used within the appropriate timeframe. Some key points to consider when handling leucovorin include:
- Always check the specific product information for stability and storage guidelines
- Use aseptic technique when handling the medication
- Discard any unused portion after reconstitution
- Store reconstituted leucovorin in the refrigerator in a light-resistant container
- Label the container with the date and time of reconstitution
- Monitor the solution for signs of degradation, such as discoloration or particles, and discard if necessary. It's also important to note that the provided studies 2, 3, 4, 5, 1 do not directly address the stability of leucovorin after opening, but they do provide information on the use of leucovorin in patients with methotrexate-induced renal dysfunction, which can inform handling and administration practices.