From the Research
Intravenous (IV) administration of Nicotinamide adenine dinucleotide (NAD) is generally more effective than subcutaneous injection, but subcutaneous administration offers certain advantages, including convenience, self-administration, and reduced discomfort. When considering the administration route for NAD therapy, it is essential to weigh the benefits and drawbacks of each method. IV NAD delivers the compound directly into the bloodstream, providing faster absorption and higher bioavailability, typically at doses ranging from 500-1000mg per session over 2-4 hours, allowing for 100% bioavailability 1. This method is particularly beneficial for those seeking rapid results for conditions like fatigue, addiction recovery, or cognitive enhancement. On the other hand, subcutaneous NAD injection, administered under the skin at lower doses (typically 100-200mg), offers a slower release with approximately 80% bioavailability, making it more convenient, and can be self-administered at home, causing less discomfort than IV therapy, and providing a more gradual, sustained release of NAD 2.
Some key factors to consider when choosing between IV and subcutaneous NAD administration include:
- Patient characteristics, such as medical status, personal attitudes toward safety and convenience, and past experience 3
- Medication administration-related factors, including dose, frequency, and formulation characteristics 3
- Health care staff and institution-related factors, such as knowledge and human resources 3
- Patient preference, which can impact treatment adherence and quality of life 4
Ultimately, the choice between IV and subcutaneous NAD administration depends on individual health goals, time constraints, and comfort preferences. IV therapy may be better suited for intensive treatment protocols requiring higher doses, while subcutaneous administration may be more appropriate for maintenance therapy or those who prefer a less invasive approach. Both methods can help increase cellular NAD levels, supporting energy production, DNA repair, and cellular resilience.