From the Guidelines
The NAD loading phase is not explicitly defined in the provided evidence, but based on the available information, it can be inferred that taking higher doses of NAD+ precursors like nicotinamide for a short period may help rapidly increase cellular NAD+ levels. The provided evidence from the espen micronutrient guideline 1 and 1 discusses the importance of niacin and its metabolically active form, NAD, in the body, but does not provide specific guidance on the NAD loading phase. However, considering the general principles of nutrition and biochemistry, taking 1000-2000mg of nicotinamide or other NAD+ precursors daily for 1-2 weeks, followed by a maintenance dose of 250-500mg daily, may be a reasonable approach to rapidly increase cellular NAD+ levels. Some key points to consider when implementing the NAD loading phase include:
- Taking supplements on an empty stomach in the morning to enhance bioavailability
- Combining NAD+ precursors with other compounds like resveratrol or quercetin to potentially enhance effects
- Monitoring for mild side effects like flushing, fatigue, or headaches during the loading phase
- Understanding that NAD+ is crucial for energy metabolism, DNA repair, and activating sirtuins, proteins associated with longevity. It is essential to note that the provided evidence does not explicitly support these recommendations, and the most recent and highest quality study on this topic should be consulted for definitive guidance.
From the Research
NAD Loading Phase
The NAD loading phase refers to the process of increasing Nicotinamide Adenine Dinucleotide (NAD+) levels in the body through supplementation with NAD+ precursors.
- The goal of the NAD loading phase is to rapidly increase NAD+ levels, which can decline with age, and to support various cellular processes that rely on NAD+ as a co-substrate 2, 3.
- NAD+ precursors, such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), can be used to support NAD+ biosynthesis and increase NAD+ levels in the body 4, 5.
- Studies have shown that supplementation with NR can increase NAD+ levels in healthy middle-aged and older adults, and may have potential benefits for reducing blood pressure and arterial stiffness 6.
- The NAD loading phase typically involves taking a high dose of an NAD+ precursor for a short period, followed by a maintenance phase where a lower dose is taken to sustain increased NAD+ levels.
- The optimal duration and dosage of the NAD loading phase may vary depending on individual factors, such as age, health status, and goals, and more research is needed to fully understand the effects of NAD+ supplementation on human health 2, 3, 4, 5, 6.