From the Guidelines
Androderm patches deliver 2-6 mg of testosterone per day. The dosage supplied by the Androderm patch is 2 mg/24-h patch, with a typical dose range of 2-6 mg/d, as indicated in Table 3 of the study by 1. This transdermal system is applied to dry, intact skin of the back, abdomen, upper thighs, or upper arms, and is known for its easy application and lack of risk of transference. However, it may cause skin rash or irritation at the site of application, and has poor adherence of the patch in some cases. The Androderm patch works by continuously releasing testosterone through the skin into the bloodstream over 24 hours, maintaining physiologic testosterone levels throughout the day.
Some key points to consider when prescribing Androderm patches include:
- Application site: Dry, intact skin of the back, abdomen, upper thighs, or upper arms
- Dosage: 2-6 mg/d, with dosage adjustments made as needed to maintain testosterone levels within the normal range
- Advantages: Easy application, no risk of transference
- Disadvantages: Skin rash or irritation at the site of application, poor adherence of the patch
It's worth noting that the study by 1 provides a comprehensive overview of testosterone replacement therapy, including various formulations and their characteristics. However, when it comes to the Androderm patch, the most important consideration is the dosage and potential side effects, as outlined above.
From the Research
Androderm Patch Testosterone Delivery
- The Androderm patch is a transdermal testosterone system designed to deliver testosterone at a controlled rate into the systemic circulation 2.
- The patch is available in different application regimens, including a single patch applied at night and removed 12 hours later, a single patch applied nightly for 24 hours, and two patches applied nightly for 24 hours 2.
- The nominal delivery rate of the Androderm patch is 2.5 mg/day for a single patch, and 5 mg/day for two patches 2.
- Studies have shown that the Androderm patch can produce physiologically appropriate testosterone levels, lower SHBG levels, promote growth and virilization, increase bone mineral density, and is generally well tolerated in hypogonadal males 2, 3, 4.
- Compared to other testosterone replacement therapies, the Androderm patch has been shown to be effective in achieving testosterone concentrations within the normal range, although it may not be superior to other formulations such as buccal systems or gels 3, 4, 5.