What is the most common subtype of Ehlers-Danlos Syndrome (EDS)?

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From the Research

Ehlers-Danlos Syndrome Subtypes

  • The most common subtype of Ehlers-Danlos Syndrome (EDS) is the hypermobile type, also known as hypermobile EDS (hEDS) 1, 2.
  • Hypermobile EDS is characterized by generalized joint hypermobility, musculoskeletal manifestations, and mild skin involvement, along with several comorbid conditions 1.
  • The genetic basis of hEDS is still unknown, and its diagnosis is currently based on clinical criteria 1, 3.

Prevalence of Hypermobile EDS

  • Hypermobile EDS is considered to be the most frequent form of EDS, and its diagnosis can be challenging due to the absence of a definite laboratory test 3.
  • Studies have shown that hEDS is the most common subtype of EDS, with a high prevalence of joint hypermobility, musculoskeletal complications, and extra-articular manifestations 4, 2.

Characteristics of Hypermobile EDS

  • Hypermobile EDS is characterized by joint pain, joint instability, and soft tissue overuse injury, which can lead to disability and chronic pain 2.
  • Extra-articular manifestations of hEDS include cardiovascular, autonomic nervous system, gastrointestinal, hematologic, ocular, gynecologic, neurologic, and psychiatric manifestations, emphasizing the multisystemic nature of the disorder 2.

References

1
Research

Hypermobile Ehlers-Danlos syndromes: Complex phenotypes, challenging diagnoses, and poorly understood causes.

Developmental dynamics : an official publication of the American Association of Anatomists, 2021

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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