What is the diagnosis and treatment for a thyroglossal duct cyst?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: February 27, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Research

The diagnosis and treatment for a thyroglossal duct cyst involves surgical removal through a procedure called the Sistrunk procedure, which includes removal of the cyst, the central portion of the hyoid bone, and the tract leading to the base of the tongue, as this approach has been shown to reduce recurrence rates to about 5-10% 1.

Diagnosis

A thyroglossal duct cyst is a congenital anomaly that occurs when the thyroglossal duct, which forms during embryonic development, fails to completely disappear. The cyst appears as a painless midline neck mass that moves upward when swallowing or sticking out the tongue. These cysts develop from remnants of the thyroglossal duct, which normally atrophies after the thyroid gland descends to its final position in the neck.

Treatment

Treatment for a thyroglossal duct cyst typically involves surgical removal through the Sistrunk procedure. This operation is recommended even for asymptomatic cysts to prevent potential complications such as infection, enlargement, or rare malignant transformation. The Sistrunk procedure has been shown to be a safe and effective procedure, with low recurrence and morbidity rates 2, 3.

  • The Sistrunk procedure includes removal of the cyst, the central portion of the hyoid bone, and the tract leading to the base of the tongue.
  • Antibiotics like amoxicillin-clavulanate may be prescribed if the cyst becomes infected before surgery, but they are not a definitive treatment.
  • Recent studies have also explored endoscopic approaches, such as the bilateral axillo-breast approach, which provides excellent cosmetic results and is a safe and better alternative for the successful treatment of TGDC 1.
  • Without complete surgical excision including the central hyoid bone, recurrence rates are high, approximately 30-40%, whereas the Sistrunk procedure reduces recurrence to about 5-10% 3, 4.

Key Considerations

  • The Sistrunk procedure is the treatment of choice for thyroglossal duct cysts because it yields low recurrence and morbidity rates 3.
  • Postoperative infections, rather than preoperative infections, are associated with recurrence 3.
  • Documentation of a normal thyroid preoperatively has become a legally protective requirement 5.
  • Carcinoma in a TGDC is unusual and is rarely detected preoperatively, but a fine needle aspiration is helpful if a malignancy is suspected 5.

References

Research

Sistrunk's operation for the treatment of thyroglossal cyst.

Mymensingh medical journal : MMJ, 2010

Research

Thyroglossal duct cyst excision.

Advances in oto-rhino-laryngology, 2012

Research

Thyroglossal duct cysts.

The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society, 1993

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.