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Differential Diagnosis for Rashes on Lips

  • Single most likely diagnosis
    • Angular cheilitis: This condition is characterized by inflammation of the corners of the mouth and can cause rashes on the lips. It is often associated with vitamin deficiencies, dry mouth, or fungal infections, making it a common diagnosis for lip rashes.
  • Other Likely diagnoses
    • Cold sore (Herpes simplex): A viral infection that causes small, fluid-filled blisters on the lips, which can be painful and may recur.
    • Contact dermatitis: An allergic reaction or irritation from substances like cosmetics, food, or metals that come into contact with the lips.
    • Eczema (Atopic dermatitis): A chronic skin condition that can cause dry, itchy, and inflamed skin on the lips.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Erythema multiforme: A skin condition that can cause target-shaped lesions on the lips and other parts of the body, often triggered by infections or medications.
    • Stevens-Johnson syndrome: A rare but life-threatening condition that can cause severe skin and mucous membrane lesions, including on the lips.
    • Lupus: A chronic autoimmune disease that can cause a variety of skin symptoms, including rashes on the lips.
  • Rare diagnoses
    • Sarcoidosis: A condition that can cause small, raised bumps on the skin, including the lips, due to inflammation.
    • Melkersson-Rosenthal syndrome: A rare neurological disorder that can cause swelling, rash, and other symptoms on the face, including the lips.
    • Pemphigus: A group of rare skin disorders that can cause blisters on the skin and mucous membranes, including the lips.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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