What are the symptoms of Systemic Lupus Erythematosus (SLE)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: July 5, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Research

Systemic Lupus Erythematosus (SLE) is characterized by a wide range of symptoms, including extreme fatigue, joint pain and swelling, butterfly-shaped rash, skin lesions, fever, and headaches, as reported in the most recent study 1.

Common Symptoms of SLE

  • Fatigue
  • Joint pain and swelling
  • Butterfly-shaped rash across the cheeks and nose
  • Skin lesions that worsen with sun exposure
  • Fever
  • Headaches
  • Raynaud's phenomenon, where fingers and toes turn white or blue when cold
  • Chest pain
  • Shortness of breath
  • Dry eyes
  • Hair loss
  • Mouth sores
  • Cognitive issues, such as memory problems or confusion

Organ-Specific Symptoms

  • Kidney problems (lupus nephritis)
  • Blood disorders, including anemia and increased risk of bleeding
  • Cardiovascular complications The symptoms of SLE can vary greatly between individuals, with many experiencing flares (periods of worsened symptoms) alternating with periods of remission, as noted in 2.

Importance of Early Recognition

Early recognition of these symptoms is crucial for prompt diagnosis and treatment to prevent organ damage and manage the disease effectively, as emphasized in 1. The most recent and highest quality study 1 provides a comprehensive overview of the symptoms and manifestations of SLE, highlighting the importance of considering the patient's experience and quality of life in the evaluation and management of the disease.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.