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Differential Diagnosis for Prostate Tenderness, Urinary Frequency, and Hematospermia

Single Most Likely Diagnosis

  • Prostatitis: This condition, which is an inflammation of the prostate gland, can cause prostate tenderness, urinary frequency, and hematospermia. The combination of these symptoms strongly suggests prostatitis, especially the acute bacterial type.

Other Likely Diagnoses

  • Benign Prostatic Hyperplasia (BPH): While BPH is more commonly associated with urinary obstruction symptoms, it can also lead to urinary frequency and, less commonly, hematospermia due to the enlarged prostate gland.
  • Prostate Cancer: Although less likely to present with these exact symptoms, prostate cancer can cause urinary frequency and hematospermia, especially in advanced stages. Prostate tenderness is not a typical presenting symptom but can be present.
  • Urethritis: Inflammation of the urethra can cause urinary frequency and, if severe, could potentially lead to hematospermia. Prostate tenderness might be referred pain.

Do Not Miss Diagnoses

  • Testicular or Epididymal Cancer: Although rare, these conditions can present with hematospermia and should not be missed due to their potential for serious outcomes if not treated early.
  • Urethral Stricture: This condition can cause urinary frequency and, if associated with trauma or infection, could potentially lead to hematospermia. It's crucial not to miss this diagnosis due to the potential for long-term urinary complications.
  • Tuberculosis of the Genitourinary Tract: This infection can cause a wide range of symptoms including hematospermia, urinary frequency, and prostate tenderness. It's essential to consider this diagnosis, especially in endemic areas or in individuals with risk factors.

Rare Diagnoses

  • Amyloidosis: A condition characterized by the deposition of amyloid proteins in various tissues, which can rarely affect the prostate and cause symptoms like hematospermia.
  • Sarcoidosis: A systemic disease that can affect any organ, including the prostate, leading to inflammation and potentially causing the symptoms described, although this would be extremely rare.
  • Malacoplakia: A rare inflammatory condition that can affect the genitourinary tract, including the prostate, and cause a variety of symptoms.

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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