From the FDA Drug Label
For treatment of tinea versicolor:
- Apply to affected areas and lather with a small amount of water.
- Allow to remain on skin for 10 minutes.
- Rinse body thoroughly.
- Repeat this procedure once a day for seven days.
The treatment for tinea versicolor using selenium sulfide (TOP) involves applying the suspension to the affected areas, allowing it to remain for 10 minutes, and then rinsing thoroughly, repeated once a day for seven days 1.
From the Research
For refractory tinea versicolor, a single dose of itraconazole 400mg is the most effective treatment option, as it has been shown to be as effective as a 7-day course of 200mg daily in clinical trials 2.
Treatment Options
- Itraconazole 400mg single dose: This treatment option has been shown to be effective in treating tinea versicolor, with a clinical response rate of 73.33% and a mycologic cure rate of 79.99% 3.
- Itraconazole 200mg daily for 5-7 days: This treatment option is also effective, with a clinical response rate of 79.99% and a mycologic cure rate of 93.33% 3.
- Fluconazole 400mg weekly for 2-4 weeks: This treatment option is also effective, with a clinical response rate of 75% and a mycologic cure rate of 77.5% 4.
Prevention of Recurrence
- Using selenium sulfide or ketoconazole shampoo as a body wash once or twice monthly can help prevent recurrence, especially in humid climates or for those who sweat heavily 5.
- Avoiding excessive heat and humidity, and wearing loose-fitting, breathable clothing can also help prevent recurrence.
Important Considerations
- Skin discoloration may persist for weeks to months after successful treatment, as this represents post-inflammatory changes rather than active infection.
- Maintenance therapy may be necessary for severe or persistent cases, such as fluconazole 400mg once monthly for several months.