What is the differential diagnosis (DDX) for incisional endometriosis?

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Last updated: February 28, 2025View editorial policy

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Differential Diagnosis for Incisional Endometriosis

Single Most Likely Diagnosis

  • Endometriosis: This is the most likely diagnosis given the presentation of incisional endometriosis, which occurs when endometrial tissue grows in a surgical scar, often after a cesarean section or other pelvic surgery. The symptoms and history typically point towards this condition.

Other Likely Diagnoses

  • Suture granuloma: A benign condition that can occur at the site of surgical scars, caused by a reaction to the suture material. It can mimic the symptoms of incisional endometriosis, such as a palpable mass and pain.
  • Hernia (e.g., spigelian or incisional hernia): A hernia occurring through a previous surgical incision can present with similar symptoms, including a bulge and discomfort.
  • Abscess or infected seroma: An infection or collection of fluid at the surgical site can cause pain, swelling, and a palpable mass, similar to incisional endometriosis.

Do Not Miss Diagnoses

  • Malignancy (e.g., sarcoma, carcinoma): Although rare, the possibility of a malignant tumor at the site of a previous surgical scar cannot be overlooked. A thorough evaluation is necessary to rule out cancer.
  • Desmoid tumor: A rare, benign but locally aggressive tumor that can occur in surgical scars. It can cause significant morbidity if not diagnosed and treated properly.

Rare Diagnoses

  • Dermoid cyst: A benign cystic teratoma that can occur in the skin, including in surgical scars. It is a rare consideration but should be kept in mind for unusual presentations.
  • Foreign body reaction: A reaction to a retained foreign body, such as a surgical sponge or instrument, can cause a mass and symptoms similar to incisional endometriosis, although this is exceedingly rare.
  • Lymphoma or other lymphoproliferative disorders: Extremely rare, but these conditions can present with masses or lesions in unusual locations, including surgical scars.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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