Is NSAID (Non-Steroidal Anti-Inflammatory Drug) safe to use in patients with dengue fever?

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Last updated: July 7, 2025View editorial policy

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From the Research

NSAIDs can be considered safe for use in patients with dengue fever, particularly when used at low doses and for short durations, as the risk of bleeding complications may be minimal, as suggested by a recent study 1. The use of NSAIDs in dengue fever has been a topic of debate, with some guidelines recommending against their use due to the potential risk of bleeding complications. However, a study published in 2019 1 suggests that the risk of bleeding associated with NSAID use in dengue fever may be lower than previously thought, particularly when used at low doses and for short durations. Some key points to consider when using NSAIDs in dengue fever include:

  • The risk of bleeding complications associated with NSAID use in dengue fever may be minimal, particularly when used at low doses and for short durations 1.
  • Acetaminophen, which is often recommended as an alternative to NSAIDs, may also have its own set of risks, including hepatotoxicity, particularly when used in high doses or for extended periods 2.
  • The decision to use NSAIDs in dengue fever should be made on a case-by-case basis, taking into account the individual patient's risk factors and medical history.
  • More recent studies, such as the one published in 2023 3, highlight the importance of considering the unique challenges and complexities of managing dengue fever in patients with comorbidities, and the need for individualized treatment approaches. It's also worth noting that other studies, such as the one published in 2020 4, suggest that the use of NSAIDs in dengue fever may be more common than previously thought, and that the risks and benefits of their use should be carefully weighed. Overall, while the use of NSAIDs in dengue fever is not without risk, the available evidence suggests that they can be considered safe for use in certain circumstances, and that the decision to use them should be made on a case-by-case basis, taking into account the individual patient's needs and medical history.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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