From the Guidelines
The recommended pediatric dose of Augmentin-ES (amoxicillin/clavulanate) for an 11-year-old male is 90 mg/kg/day of the amoxicillin component, divided into two doses given every 12 hours. For an average 11-year-old weighing approximately 35-40 kg, this would typically mean about 1575-1800 mg of amoxicillin component twice daily.
Key Considerations
- Augmentin-ES contains 600 mg of amoxicillin and 42.9 mg of clavulanate per 5 mL of suspension, and the exact dose should be calculated based on the child's actual weight 1.
- The medication should be taken with food to reduce gastrointestinal side effects, and the suspension should be refrigerated after reconstitution and used within 10 days.
- It's essential to complete the full course of antibiotics (typically 10 days) even if symptoms improve before then, as this ensures the infection is fully cleared and reduces the risk of antibiotic resistance.
Rationale
- The dose of 90 mg/kg/day is defined as high-dose amoxicillin/clavulanate for children, which is necessary for effectively treating infections caused by penicillin-nonsusceptible S pneumoniae and β-lactamase–producing organisms 1.
- Augmentin-ES is a higher concentration formulation specifically designed for more serious infections like acute otitis media, sinusitis, or pneumonia, providing enhanced coverage against resistant strains of Streptococcus pneumoniae while maintaining effectiveness against beta-lactamase producing bacteria.
From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
Pediatric Dose of Augmentin-ES
The pediatric dose of Augmentin-ES (amoxicillin/clavulanate) can be determined based on the available evidence.
- The recommended dose for pediatric use is 90/6.4 mg/kg/day in two divided doses 2, 3.
- This dose is specifically for persistent or recurrent acute otitis media where there are risk factors for the involvement of beta-lactamase-producing strains or S. pneumoniae with reduced penicillin susceptibility 2.
- For an 11-year-old male, the dose would depend on the child's weight, as the dose is calculated based on kg/day.
- There is no specific information provided in the studies about the exact weight range for an 11-year-old male, but the dose can be calculated based on the child's actual weight.
- It is essential to consult a healthcare professional to determine the exact dose and treatment duration for the child.