From the FDA Drug Label
Neisseria gonorrhoeae
The drug exerts high in vitro activity against ... Neisseria gonorrhoeae
- Gonorrhoea is sensitive to penicillin V.
- There is no information about the sensitivity of gonorrhoea to co-amoxiclav in the provided drug label 1.
From the Research
Gonorrhea is generally not sensitive to co-amoxiclav (Augmentin) or penicillin V, and these antibiotics should not be used to treat gonorrhea infections. Due to widespread antimicrobial resistance, most strains of Neisseria gonorrhoeae now produce beta-lactamase enzymes that inactivate penicillins, making these medications ineffective 2. The current recommended first-line treatment for uncomplicated gonorrhea is a single intramuscular injection of ceftriaxone 500mg, which may be combined with azithromycin or doxycycline, particularly if chlamydial co-infection is suspected 3, 4.
Key Points to Consider
- The use of co-amoxiclav or penicillin V is not recommended due to high resistance rates 5, 6
- Ceftriaxone remains effective against most gonorrhea strains despite increasing resistance to other antibiotics 3, 4
- Treatment guidelines may vary by region based on local resistance patterns, and patients should be tested for cure following treatment
- All sexual partners from the previous 60 days should be notified, tested, and treated to prevent reinfection and further transmission
Recommended Treatment Approach
- Use ceftriaxone 500mg as the first-line treatment for uncomplicated gonorrhea
- Consider combining ceftriaxone with azithromycin or doxycycline if chlamydial co-infection is suspected
- Avoid using co-amoxiclav or penicillin V due to high resistance rates
- Monitor local resistance patterns and adjust treatment guidelines accordingly 3, 4