What clotting factor correlates with Vitamin K (Vit. K)?

From the Guidelines

Vitamin K correlates with clotting factors II, VII, IX, and X. The correlation between Vitamin K and clotting factors is well established, with factors II, VII, IX, and X being the primary clotting factors that depend on Vitamin K for their synthesis and biological activity 1. These clotting factors are essential for the coagulation cascade, and Vitamin K serves as a cofactor for the enzyme gamma-glutamyl carboxylase, which adds carboxyl groups to glutamic acid residues on these proteins, allowing them to bind calcium and attach to phospholipid surfaces. Some key points to consider include:

• The onset of effect of Vitamin K depends on the route of administration, with intravenous administration having a faster onset than oral administration 1.
• The dose of Vitamin K should be predicated on the presence of active bleeding, the maintenance dose of the VKA, the magnitude of INR elevation, and the desired range into which to reduce the INR 1.
• Four-factor prothrombin complex concentrate, which includes factors II, VII, IX, and X, is a more specific and reliable reversal agent than fresh frozen plasma 1. Given the most recent and highest quality evidence, the correct answer is that Vitamin K correlates with clotting factors II, VII, IX, and X, which is supported by the 2021 ACC/AHA guideline for the management of patients with valvular heart disease 1.

From the Research

Clotting Factors Correlating with Vitamin K

The clotting factors that correlate with Vitamin K (Vit. K) are:

• Factor II (Prothrombin) 2, 3, 4
• Factor VII 2, 5, 3, 4
• Factor IX 2, 3, 4
• Factor X 2, 6, 3, 4

Specific Clotting Factor Correlation

Based on the provided options, the correct answer is:

• C. X (Factor X) 2, 6, 3, 4 Other options, A. VII (Factor VII) and B. XI, are not the best answer choice, although Factor VII is also a Vitamin K-dependent clotting factor 2, 5, 3, 4. Factor XI is not mentioned as a Vitamin K-dependent clotting factor in the provided studies.