What is the normal range of urine osmolality (milliosmoles per kilogram) in pregnancy?

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Last updated: July 7, 2025View editorial policy

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From the Research

The normal range of urine osmolality during pregnancy is typically less than 500 milliosmoles per kilogram (mOsm/kg), as values above this threshold may indicate inadequate fluid intake and decreased hydration status, according to the most recent study 1.

Key Points

  • Urine osmolality reflects the renal regulation of excess fluid or deficit fluid and serves as a marker of hydration status 2.
  • Physiological changes in kidney function during pregnancy lead to increased glomerular filtration rate and altered tubular reabsorption, resulting in a tendency toward more dilute urine.
  • The lower urine osmolality reflects the body's adaptation to pregnancy, which includes increased water retention to support the expanded blood volume needed for fetal development and placental function.
  • Urine color can be used as a practical and valid marker of urine concentration in pregnant and lactating women, with a urine color of 4 or more indicating a urine osmolality of 500 mOsm/kg or higher 1.

Clinical Implications

  • Pregnant women should aim to maintain a urine osmolality below 500 mOsm/kg to ensure adequate hydration status.
  • Urine color can be used as a simple and non-invasive tool to monitor hydration status in pregnant and lactating women.
  • Women who present with a urine color of 4 or more should consider increasing their fluid consumption to improve hydration status 1.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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