Differential Diagnosis for Medial Corner of Eye Puffy

• Single most likely diagnosis
  • Allergic conjunctivitis: This condition is characterized by inflammation of the conjunctiva due to an allergic reaction, which can cause puffiness, especially in the medial corner of the eye where the lacrimal sac is located.
• Other Likely diagnoses
  • Blepharitis: Inflammation of the eyelids can cause swelling and puffiness, particularly in the medial corner where the eyelids meet.
  • Lacrimal sac inflammation or dacryocystitis: Infection or blockage of the lacrimal sac can lead to swelling and puffiness in the medial corner of the eye.
  • Sinusitis: Since the sinuses are located near the eyes, inflammation or infection of the sinuses can cause puffiness and swelling around the eyes, including the medial corner.
• Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
  • Orbital cellulitis: A serious infection of the tissues surrounding the eye, which can cause severe swelling, including in the medial corner, and requires prompt medical attention.
  • Thyroid ophthalmopathy: Although less common, this condition associated with thyroid disease can cause swelling and puffiness around the eyes, including the medial corner, and has significant implications for vision and overall health.
• Rare diagnoses
  • Sarcoidosis: A systemic disease that can cause inflammation in various parts of the body, including the eyes, leading to swelling and puffiness.
  • Granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis): A rare autoimmune disorder that can affect the eyes and sinuses, causing inflammation and swelling, including in the medial corner of the eye.