From the Research
Metoclopramide (Reglan) can decrease the effectiveness of lamotrigine (Lamictal) by potentially reducing its blood levels, and patients taking both medications should be monitored for decreased seizure control or mood stabilization effects from lamotrigine. This interaction occurs because metoclopramide accelerates gastric emptying, which may reduce lamotrigine absorption in the intestines 1. Additionally, both medications can cause central nervous system side effects, potentially leading to increased drowsiness, dizziness, or coordination problems when used together.
Some key points to consider when using these medications together include:
- Monitoring for decreased efficacy of lamotrigine, such as increased seizure frequency or decreased mood stabilization
- Potential for increased central nervous system side effects, such as drowsiness or dizziness
- The need for potential dosage adjustments or closer monitoring of lamotrigine levels when used with metoclopramide
It's also important to note that lamotrigine has no significant effect on hepatic drug metabolism, according to a study published in 1996 1. However, the interaction between metoclopramide and lamotrigine is not directly addressed in the provided evidence, and the information is based on the general principles of pharmacology and potential interactions between medications.
If both medications are necessary, healthcare providers might need to adjust the lamotrigine dosage or monitor levels more closely. Patients should report any changes in seizure frequency, mood symptoms, or new side effects to their healthcare provider immediately. This interaction is particularly important for patients with epilepsy or bipolar disorder who rely on consistent lamotrigine levels for symptom control.