Is Dermasmooth F/S (fluocinolone acetonide) safe to use in patients with a peanut allergy?

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Last updated: July 7, 2025View editorial policy

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From the Research

Dermasmooth F/S (fluocinolone acetonide) can be safely used in patients with peanut allergies, as the refined peanut oil it contains has been shown to be non-allergenic in multiple studies. The oil base of Dermasmooth F/S contains refined peanut oil, which has undergone a process that removes most allergenic proteins, making it safe for use in peanut-allergic individuals 1, 2, 3. While there is a small theoretical risk of reaction in highly sensitive patients, the majority of the evidence suggests that refined peanut oil is safe for most peanut-allergic individuals.

Some key points to consider when prescribing Dermasmooth F/S to a patient with a known peanut allergy include:

  • The refining process of peanut oil removes most allergenic proteins, reducing the risk of an allergic reaction 1
  • Multiple studies have demonstrated the safety and efficacy of fluocinolone acetonide 0.01% in refined peanut oil in patients with atopic dermatitis, including those with peanut sensitivity 2, 3
  • No evidence of adrenal suppression or adverse local effects was demonstrated in these studies 2, 3
  • The medication was well tolerated in patients with peanut allergic sensitivity 2

It is essential to note that while the evidence suggests that Dermasmooth F/S is safe for use in patients with peanut allergies, it is always best to exercise caution and consider individual patient factors, such as the severity of the allergy and any previous reactions. However, based on the current evidence, Dermasmooth F/S can be a viable treatment option for patients with peanut allergies.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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