Is Ezetia (ezetimibe) contraindicated with Vardenafil (levitra)?

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Last updated: February 28, 2025View editorial policy

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From the Guidelines

There is no direct contraindication between Ezetia (ezetimibe) and Vardenafil (levitra) based on the provided evidence, and they can be used together with caution, as they work through different mechanisms and have different primary effects in the body. The provided evidence does not discuss the interaction between Ezetia and Vardenafil directly [ 1 ]. However, it is essential to consider potential interactions with other medications and individual patient factors such as liver function, age, and other medications being taken simultaneously, which could influence how these drugs are tolerated when used together. Key points to consider when using these medications together include:

  • Ezetia reduces cholesterol absorption in the small intestine to help lower LDL cholesterol levels
  • Vardenafil is a phosphodiesterase-5 (PDE5) inhibitor used to treat erectile dysfunction
  • Patients should inform their healthcare providers about all medications they are taking to monitor for potential drug interactions
  • Certain medications may affect the metabolism of either drug, and individual patient factors could influence how these drugs are tolerated when used together. It is crucial to prioritize the patient's overall health and monitor for any potential interactions or adverse effects when using these medications together [ 1 ].

From the Research

Ezetia (Ezetimibe) and Vardenafil (Levitra) Interaction

  • There is no direct evidence in the provided studies that suggests a contraindication between Ezetia (ezetimibe) and Vardenafil (levitra) 2, 3, 4, 5, 6.
  • The studies primarily focus on the cardiovascular effects of phosphodiesterase 5 inhibitors, such as vardenafil, and their interactions with other medications, particularly those related to cardiovascular disease and erectile dysfunction.
  • Vardenafil is known to interact with certain medications, such as nitrates and alpha-adrenoceptor blockers, which can lead to significant hypotension or other adverse effects 2, 3, 4.
  • However, there is no mention of ezetimibe, a medication used to lower cholesterol, as a contraindicated drug with vardenafil in the provided studies.
  • It is essential to consult a healthcare professional for personalized advice on potential drug interactions, as individual patient factors and medication regimens can influence the safety and efficacy of concomitant drug use.

Relevant Drug Interactions

  • Nitrates and alpha-adrenoceptor blockers are contraindicated with vardenafil due to the risk of significant hypotension 2, 4.
  • Other medications, such as erythromycin and HIV protease inhibitors, may interact with vardenafil, but the evidence does not suggest a direct interaction with ezetimibe 3.

References

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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