What is the frequency of administration for Ondansetron (Zofran) 8 milligrams?

From the Guidelines

Ondansetron 8 mg should be administered twice daily for the management of nausea and vomiting, as recommended by the most recent and highest quality study 1. The frequency of administration for Ondansetron (Zofran) 8 milligrams is a crucial aspect of its effectiveness in preventing nausea and vomiting. According to the American Society of Clinical Oncology clinical practice guideline update 1, Ondansetron can be administered orally at a dose of 8 mg twice daily. This dosing regimen is applicable to various emetic risk categories, including high-risk and moderate-risk chemotherapy.

• Key points to consider:
  • The dose of Ondansetron can be administered orally, with or without food, and should be taken with a full glass of water.
  • For orally disintegrating tablets (ODT), the tablet should be allowed to dissolve on the tongue without water.
  • The maximum daily dose of Ondansetron is 24 mg (or three 8 mg doses) in a 24-hour period.
  • Side effects may include headache, constipation, and occasionally dizziness.
  • If nausea persists despite taking Ondansetron as prescribed, patients should contact their healthcare provider, as this could indicate a more serious condition requiring different treatment. The NCCN Guidelines Insights: Antiemesis, version 2.2017 1 also support the use of Ondansetron in antiemetic regimens for chemotherapy-induced nausea and vomiting, although the specific dosing recommendations may vary depending on the emetogenic potential of the antitumor therapies and individual patient factors. However, the most recent and highest quality study 1 provides the most up-to-date guidance on the frequency of administration for Ondansetron 8 mg.

From the FDA Drug Label

In a double-blind US trial in 336 patients receiving a cyclophosphamide-based chemotherapy regimen containing either methotrexate or doxorubicin, ondansetron tablets 8 mg administered twice a day, was as effective as ondansetron tablets 8 mg administered 3 times a day in preventing nausea and vomiting The first 8 mg dose was administered 30 minutes before the start of emetogenic chemotherapy, with a subsequent 8 mg dose 8 hours after the first dose, followed by 8 mg administered twice a day for 2 days after the completion of chemotherapy

The frequency of administration for Ondansetron (Zofran) 8 milligrams is twice a day or three times a day, depending on the specific regimen. However, the most relevant information for the 8mg dose is that it can be administered twice a day. 2

From the Research

Administration Frequency of Ondansetron (Zofran) 8 milligrams

• The administration frequency of Ondansetron (Zofran) 8 milligrams is not explicitly stated in the provided studies as a single, unified recommendation.
• However, according to the study 3, ondansetron can be administered as 8mg 4-hourly for 3 doses.
• Another study 4 mentions that ondansetron was given as an 8 mg loading dose before chemotherapy followed by 8 mg every 8 hours orally for 3 to 5 days.
• Study 5 also administered ondansetron 8 mg iv 30 min prior to cisplatin administration followed by 8 mg ondansetron orally 8 h respectively for 24 h after the last cisplatin administration.
• It is essential to consult the specific prescribing information or a healthcare professional for the most accurate and up-to-date administration guidelines for ondansetron, as the frequency may vary depending on the individual patient's needs and the specific context of use 6, 7, 3, 4, 5.