From the Research
Roundup (glyphosate) is likely a cause of non-Hodgkin lymphoma, including chronic lymphocytic leukemia (CLL), as evidenced by the International Agency for Research on Cancer (IARC) classification of glyphosate as probably carcinogenic to humans 1. The link between Roundup (glyphosate) and CLL remains scientifically controversial, but the most recent and highest quality study suggests a potential association between exposure to glyphosate-based formulations (GBFs) and an increased risk of non-Hodgkin lymphoma, including CLL 1. Some key points to consider:
- The IARC concluded that glyphosate and GBFs are probably carcinogenic to humans, mainly for non-Hodgkin lymphoma (NHL) 1.
- Epidemiologic studies provide ample evidence for an association between exposure to GBFs and an increased risk of NHL 1.
- Animal studies have shown that glyphosate is carcinogenic in rodents and causes NHL in mice 1.
- Mechanistic studies have demonstrated that glyphosate and GBFs are genotoxic to human lymphocytes, the normal cell of origin of NHL, both in vitro and in vivo 1. However, it's essential to note that while some studies have found associations between Roundup exposure and increased risk of certain blood cancers, definitive causation has not been established. To minimize potential risks, people working with Roundup should:
- Use protective equipment
- Follow application instructions carefully
- Wash thoroughly after handling the product It's crucial to prioritize morbidity, mortality, and quality of life when considering the potential risks associated with Roundup exposure and CLL development.