What is the maximum duration Humira (adalimumab) can be stored at room temperature?

Maximum Duration for Room Temperature Storage of Humira

Humira (adalimumab) can be stored at room temperature (up to 77°F/25°C) for a maximum of 14 days, after which it must be discarded if unused. 1

Storage Requirements for Humira

Official Storage Guidelines

The FDA-approved drug label for Humira provides clear instructions regarding storage:

• Primary storage should be in a refrigerator between 36°F to 46°F (2°C to 8°C)
• When refrigeration is not possible, Humira may be stored at room temperature up to 77°F (25°C) for up to 14 days
• Humira must be discarded if kept at room temperature for more than 14 days
• The medication should be protected from light by keeping it in its original carton 1

Temperature Considerations

Room temperature storage is defined as approximately 68-77°F (20-25°C) according to pharmaceutical standards. It's important to note that:

• Humira should never be exposed to extreme heat or cold (such as in a hot car or freezer)
• Once removed from refrigeration, the 14-day countdown begins regardless of whether the medication is later returned to the refrigerator
• The medication should not be frozen at any point 1

Clinical Implications

Medication Efficacy and Safety

Proper storage of Humira is critical for maintaining its efficacy and safety:

• Temperature excursions beyond recommended ranges may affect the stability and potency of the medication
• Studies have shown that improper storage temperatures can potentially compromise biologic medications like adalimumab 2

Common Storage Pitfalls to Avoid

Research has identified several common issues with home storage of temperature-sensitive medications like Humira:

• Using older refrigerators (>5 years old) increases the risk of improper storage temperatures 2
• Approximately 58% of patients may store their biologic medications outside the correct temperature range 2
• Placing medication in areas of the refrigerator with temperature fluctuations (like door shelves)

Practical Recommendations

1. When traveling, use insulated containers with cooling packs to maintain appropriate temperature
2. Keep track of how long the medication has been at room temperature
3. Never use Humira that has been stored improperly or beyond the 14-day room temperature limit
4. Store in a consistent location away from heat sources and direct sunlight
5. Do not store in bathroom medicine cabinets where temperature and humidity fluctuate

Following these storage guidelines will help ensure that Humira maintains its intended therapeutic effect and safety profile throughout its use.