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Last updated: July 10, 2025View editorial policy

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Differential Diagnosis for Redness and Pain between 1st and 2nd Toe

  • Single most likely diagnosis
    • Interdigital candidiasis or athlete's foot: This condition is common and often presents with redness, itching, and pain in the interdigital spaces, particularly between the 1st and 2nd toes due to moisture retention.
  • Other Likely diagnoses
    • Ingrown toenail: This condition can cause redness, swelling, and pain, especially if the nail grows into the skin between the 1st and 2nd toes.
    • Interdigital neuroma (Morton's neuroma): Although more common between the 3rd and 4th toes, it can occur between any toes, causing pain and sometimes redness due to nerve irritation.
    • Bursitis: Inflammation of a bursa between the toes can cause pain, redness, and swelling.
  • Do Not Miss diagnoses
    • Cellulitis: A bacterial infection of the skin that can spread rapidly and cause serious complications if not treated promptly. It presents with redness, swelling, warmth, and pain.
    • Deep vein thrombosis (DVT): Although less common in the foot, DVT can cause pain and swelling, and it's crucial to consider it due to its potential for severe complications like pulmonary embolism.
    • Osteomyelitis: A bone infection that can cause pain, redness, and swelling, and is a serious condition requiring prompt treatment.
  • Rare diagnoses
    • Erythromelalgia: A rare disorder characterized by burning pain, heat, and redness in the hands and feet, which could potentially cause symptoms between the toes.
    • Gout or pseudogout: Although these conditions more commonly affect the big toe, they can cause sudden, severe pain and redness in other toes as well.
    • Complex regional pain syndrome (CRPS): A rare condition characterized by intense burning or aching pain in the hands or feet after an injury or trauma, which could potentially involve the area between the toes.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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