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Differential Diagnosis for Rash between First and Second Toe

Single Most Likely Diagnosis

  • Interdigital candidiasis: This is a common condition caused by a fungal infection, typically Candida, which thrives in warm, moist environments like the space between toes. The location and description of the rash make this a highly probable diagnosis.

Other Likely Diagnoses

  • Tinea pedis (athlete's foot): A fungal infection that can cause rash, itching, and cracking of the skin, often found between the toes.
  • Eczema (dyshidrotic eczema): Characterized by small, itchy blisters on the feet, including between the toes.
  • Contact dermatitis: An allergic reaction or irritation from substances like soap, detergent, or certain materials in shoes, which can cause a rash in the affected area.

Do Not Miss Diagnoses

  • Cellulitis: A bacterial skin infection that can cause redness, swelling, and warmth, potentially serious if not treated promptly.
  • Erythrasma: A bacterial infection that can cause a rash, typically in the intertriginous areas (skin folds), and is often mistaken for a fungal infection.
  • Squamous cell carcinoma: Although rare, any persistent or changing skin lesion should be evaluated for the possibility of skin cancer.

Rare Diagnoses

  • Pitted keratolysis: A bacterial infection that causes small pits in the skin, often accompanied by a foul odor, typically found on the soles of the feet but can occur between toes.
  • Keratoderma blennorrhagicum: Associated with reactive arthritis, this condition causes skin lesions on the feet, among other symptoms.
  • Granuloma glutiale infantum: A rare condition causing granulomatous lesions in the skin folds, including between the toes, typically in response to irritants or infections.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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