What are the guidelines for managing difficult airways in 2022?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: July 11, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

2022 Difficult Airway Management Guidelines

The 2022 difficult airway management guidelines emphasize using videolaryngoscopy as the first-line approach for patients with suspected or confirmed difficult airways, with a structured algorithm for rescue techniques when initial attempts fail. 1

Airway Assessment and Prediction

Key Assessment Components:

  • Predictors of difficult direct laryngoscopy:
    • Modified Mallampati classification (Class 3-4 correlates with Cormack-Lehane Grade 2-4) 2
    • Thyromental distance (highest sensitivity and negative predictive value) 3
    • Upper lip bite test (highest specificity) 3
    • Inter-incisor gap
    • Atlantooccipital extension
    • LEMON assessment (Look, Evaluate, Mallampati, Obstruction, Neck mobility)

Risk Stratification:

  • Multiple attempts at tracheal intubation increase patient morbidity 4
  • When difficulty is anticipated, limit attempts to maximum of three with any chosen device 4
  • Consider awake approach when multiple aspects of airway management are predicted to be difficult 5

Management Algorithm for Difficult Airways

First-Line Approach:

  • Videolaryngoscopy is recommended as first-line for patients with suspected or confirmed difficult airways (Grade A; moderate recommendation) 1
  • No specific videolaryngoscope type or blade is recommended over others 1
  • Regular training with videolaryngoscopy in simulated difficult airway scenarios is essential 1

Airway Techniques:

  1. For basic airway maneuvers:

    • Use jaw thrust rather than head tilt-chin lift when cervical spine injury is suspected 1
    • Minimize cervical spine movement during pre-oxygenation and facemask ventilation 1
  2. For supraglottic airway devices (SADs):

    • Second-generation SADs are preferred over first-generation devices 1
    • Use familiar devices when intubating through an SAD 1
    • Consider using adjuncts (stylet or bougie) when performing tracheal intubation 1
  3. For predicted difficult intubation:

    • Consider awake tracheal intubation when:
      • Impossible videolaryngoscopy or direct laryngoscopy is predicted
      • Multiple modes of airway management are predicted to be difficult
      • Physiological or contextual issues increase risk 5

Rescue Techniques:

  1. If initial intubation fails:

    • Transition through algorithm promptly
    • Declare difficulty to the team at each stage
    • Consider second-generation SAD between attempts (better seal, less aerosol generation) 1
  2. Cannot Intubate, Cannot Oxygenate (CICO) scenario:

    • Follow emergency front-of-neck airway (FONA) protocol
    • Scalpel-bougie-tube technique is preferred (especially in COVID-19 patients) 1
    • Maximum three attempts at each lifeline before escalating 1

Post-Intubation Management

  1. After successful intubation:

    • Inflate cuff to 20-30 cmH₂O pressure immediately 1
    • Secure tube and confirm placement with waveform capnography 1
    • Document depth of insertion prominently 1
    • Consider early placement of nasogastric tube to minimize later interventions 1
  2. Ongoing management:

    • Use closed tracheal suction when available 1
    • Monitor cuff pressure and tube depth at every shift 1
    • Check tube position before and after patient repositioning 1
    • Document and communicate difficult airway details at shift changes 1

Common Pitfalls and Caveats

  • Overreliance on single predictors: No single airway test provides high sensitivity and specificity; combine multiple tests 3
  • Delayed recognition of failure: Define clear triggers for moving from one technique to the next 5
  • Inadequate preparation: Ensure difficult airway equipment is readily available before induction 5
  • Failure to anticipate: Preoperative anticipation of difficult airways occurs in only 50% of cases; always have a backup plan 6
  • Extubation risks: Carefully plan extubation of at-risk patients, including assessment of tolerance for airway support withdrawal 5

The guidelines emphasize that while prediction tools are helpful, unanticipated difficulty can always occur, necessitating a prepared strategy for every patient and institutional readiness with appropriate equipment.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.