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Last updated: July 13, 2025View editorial policy

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Differential Diagnosis for Subconjunctival Hemorrhage

  • Single most likely diagnosis
    • Hypertension: This is often the most common cause of spontaneous subconjunctival hemorrhage, especially in older adults, due to the rupture of small blood vessels under the conjunctiva.
  • Other Likely diagnoses
    • Trauma: Direct injury to the eye can cause subconjunctival hemorrhage by rupturing the small blood vessels under the conjunctiva.
    • Bleeding disorders (e.g., hemophilia, thrombocytopenia): Conditions that affect blood clotting can increase the risk of subconjunctival hemorrhage.
    • Anticoagulant use: Medications that prevent blood clotting, such as warfarin or aspirin, can increase the risk of subconjunctival hemorrhage.
    • Sudden increase in pressure (e.g., coughing, sneezing, straining): These actions can increase pressure in the small blood vessels under the conjunctiva, leading to rupture.
  • Do Not Miss diagnoses
    • Orbital cellulitis or abscess: Although rare, these conditions can cause subconjunctival hemorrhage and are medical emergencies requiring prompt treatment.
    • Malignant hypertension: Severe uncontrolled hypertension can lead to subconjunctival hemorrhage and indicates a need for immediate blood pressure management.
    • Vasculitis (e.g., giant cell arteritis, polyarteritis nodosa): Inflammatory conditions affecting blood vessels can cause subconjunctival hemorrhage and require specific treatment.
  • Rare diagnoses
    • Amyloidosis: Deposits of abnormal proteins (amyloid) in the blood vessels under the conjunctiva can weaken them and lead to hemorrhage.
    • Scurvy (Vitamin C deficiency): This condition can cause blood vessel fragility, leading to subconjunctival hemorrhage among other symptoms.
    • Ehlers-Danlos syndrome: A genetic disorder affecting connective tissue, which can lead to fragile blood vessels and increased risk of subconjunctival hemorrhage.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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