From the Guidelines
Magnesium supplements, specifically magnesium oxide (MgO), are a beneficial and attractive first-line option for individuals with chronic idiopathic constipation (CIC), with a recommended dose of 500 mg/d to 1 g/d. The benefits of magnesium supplements include their ability to create an osmotic gradient in the GI tract, leading to net secretion of water and electrolytes, which can exert a beneficial effect on constipation-related symptoms 1. Additionally, magnesium supplements have been shown to be well-tolerated, with no increased reports of diarrhea compared to placebo 1.
When considering magnesium supplementation, it is essential to take into account the potential risks, particularly in individuals with renal impairment. Magnesium supplements should be avoided in individuals with a creatinine clearance of <20 mg/dL due to the risk of hypermagnesemia 1. It is also recommended to start with a lower dose and increase as necessary, and to avoid use in patients with renal insufficiency 1.
The benefits of magnesium supplements extend beyond constipation, and may also include managing conditions like migraines, anxiety, insomnia, and muscle cramps. However, it is crucial to note that the efficacy and safety of magnesium supplements for these conditions may vary, and further research is needed to fully understand their effects.
In terms of administration, it is recommended to take magnesium supplements with food to minimize digestive discomfort, and to divide larger doses throughout the day. Blood tests can determine if an individual has a deficiency before starting supplementation, and it is essential to consult with a doctor before taking magnesium supplements, particularly for individuals with kidney disease.
From the Research
Benefits of Magnesium Supplements
The benefits of magnesium (Mg) supplements are numerous and well-documented in various studies 2, 3, 4, 5, 6. Some of the key benefits include:
- Improving insulin sensitivity and secretion in patients with type 2 diabetes 4, 5, 6
- Reducing the risk of chronic diseases such as hypertension, cardiovascular disease, and type 2 diabetes mellitus 2, 3
- Preventing and treating magnesium deficiency, which can contribute to pathological processes 2
- Regulating muscular contraction, blood pressure, and cardiac excitability 3
- Playing a crucial role in energy metabolism, glucose utilization, and protein synthesis 2, 3
Magnesium and Diabetes
Magnesium supplements have been shown to have a positive effect on diabetes management, particularly in patients with type 2 diabetes 4, 5, 6. The benefits include:
- Improving insulin sensitivity and secretion 4, 5, 6
- Reducing the development of type 2 diabetes in predisposed individuals 5
- Decreasing the risk of retinopathy and other diabetes-related complications 5
- Regulating intracellular Mg concentrations, which is important for insulin action and glucose uptake 6
Overall Health Benefits
Magnesium supplements can also have a positive impact on overall health, including: