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Last updated: July 14, 2025View editorial policy

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Differential Diagnosis for Skin Rash

  • Single Most Likely Diagnosis
    • Atopic Dermatitis (Eczema): This is a common condition characterized by itchy, inflamed skin. It's often seen in individuals with a history of allergies or asthma, and its prevalence makes it a likely diagnosis for a skin rash.
  • Other Likely Diagnoses
    • Contact Dermatitis: An allergic or irritant reaction to substances like soaps, detergents, or metals, leading to a skin rash. This is common and can occur in anyone.
    • Psoriasis: An autoimmune condition causing red, scaly patches on the skin. It's relatively common and can be triggered by various factors, including stress and certain medications.
    • Seborrheic Dermatitis: A condition causing scaly patches, red skin, and stubborn dandruff, often affecting oily areas of the body. It's common and can be linked to stress, cold weather, and other factors.
  • Do Not Miss Diagnoses
    • Meningococcemia: A severe infection that can cause a rash, often accompanied by fever, headache, and stiff neck. It's life-threatening and requires immediate medical attention.
    • Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A severe skin condition usually caused by an adverse reaction to medication, leading to blistering and peeling of the skin. It's rare but potentially fatal.
    • Lyme Disease: A bacterial infection from a tick bite, which can cause a distinctive "bull's-eye" rash, along with fever, headache, and fatigue. If untreated, it can lead to serious complications.
  • Rare Diagnoses
    • Pemphigus: A group of autoimmune diseases causing blistering of the skin and mucous membranes. It's rare and can be life-threatening if not treated.
    • Kawasaki Disease: A condition mainly affecting children, causing fever, rash, and swelling, with potential for serious cardiac complications if not treated promptly.
    • Erythema Multiforme: An immune-mediated disorder causing skin lesions, often in response to infections or medications. It's rare and can range from mild to severe.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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