What is the diagnostic approach for a sprain?

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Last updated: July 14, 2025View editorial policy

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Diagnosing a Sprain

The diagnosis of a sprain should focus on a thorough history of injury mechanism, physical examination findings, and application of validated clinical decision rules like the Ottawa Ankle Rules to rule out fractures before confirming a ligament injury. 1

History Assessment

When evaluating a potential sprain, gather the following key information:

  • Mechanism of injury (inversion, eversion, plantar flexion)
  • Timing of the injury
  • History of previous sprains (a significant risk factor)
  • Immediate symptoms (pain, swelling, ability to bear weight)
  • Presence of high-risk features requiring urgent evaluation:
    • High level of pain
    • Rapid onset of swelling
    • Coldness or numbness in the injured area
    • Inability to bear weight
    • Complicating conditions (e.g., diabetes) 1

Physical Examination

The physical examination should include:

  • Visual inspection for swelling and hematoma
  • Palpation for point tenderness over specific ligaments
  • Special tests:
    • Anterior drawer test for anterior talofibular ligament injury
    • Crossed-leg test for high ankle (syndesmotic) sprains 1

Key Physical Findings for Grade III Sprains

Four key physical examination findings strongly associated with lateral ligament rupture:

  1. Swelling
  2. Hematoma
  3. Pain on palpation
  4. Positive anterior drawer test

When all four findings are present, 96% of patients have a lateral ligament rupture; when all are absent, only 14% have a rupture. 1

Timing of Examination

  • Initial examination may be limited by pain and swelling
  • Reexamination 3-5 days after injury is critical for distinguishing partial tears from complete ligament ruptures 1
  • The sensitivity (84%) and specificity (96%) of the anterior drawer test are optimized when assessment is delayed for 4-5 days post-injury 1

Ottawa Ankle Rules

The Ottawa Ankle Rules should be applied to determine the need for radiography:

  • Pain on the dorsal side of one or both malleoli
  • Palpation pain at the base of the fifth metatarsal
  • Palpation pain of the navicular bone
  • Inability to walk at least four steps 1

These rules have excellent sensitivity (86-99%) and negative predictive value (97-99%), allowing clinicians to safely rule out fractures without radiography in 299 out of 300 patients. 1

Grading System for Sprains

Sprains are typically classified into three grades:

  • Grade I (Mild): Minimal stretching of ligament fibers with microscopic tearing
  • Grade II (Moderate): Partial tearing of ligament with some joint laxity
  • Grade III (Severe): Complete ligament tear with joint instability 1

Advanced Imaging

  • Ultrasonography: High sensitivity (92%) but lower specificity (64%) compared to delayed examination; requires experienced technician 1
  • MRI: Excellent sensitivity (93-96%) and specificity (100%) for visualizing ligament injuries, osteochondral defects, and occult fractures 1
  • Reserve MRI for cases with:
    • Suspicion of high-grade ligament injuries
    • Possible osteochondral defects
    • Syndesmotic injuries
    • Occult fractures
    • Persistent symptoms 1

Common Pitfalls to Avoid

  1. Premature diagnosis: Examining too early when pain and swelling limit assessment
  2. Unnecessary imaging: Failing to apply Ottawa Ankle Rules properly
  3. Missing associated injuries: Not considering syndesmotic injuries or osteochondral lesions
  4. Inadequate follow-up: Not reassessing after swelling subsides
  5. Overlooking previous injury history: Not recognizing recurrent sprains as risk factors for chronic instability 1

Diagnostic Algorithm

  1. Assess injury mechanism and immediate symptoms
  2. Apply Ottawa Ankle Rules to determine need for radiography
  3. If radiographs are negative or not indicated, perform physical examination
  4. If examination is limited by pain/swelling, schedule follow-up in 3-5 days
  5. At follow-up, perform anterior drawer test and other special tests
  6. Consider advanced imaging only for persistent symptoms or suspected complications 1

Following this systematic approach will help ensure accurate diagnosis of sprains and appropriate management to prevent chronic instability and long-term complications.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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