From the FDA Drug Label
The recommended dosage of DUPIXENT for pediatric patients 6 years to 17 years of age is specified in Table 2
Table 2: Dosage of DUPIXENT in Pediatric Patients 6 Years to 17 Years of Age with Atopic Dermatitis
Body Weight | Initial Loading Dose | Subsequent Dosage
15 to less than 30 kg | 600 mg (two 300 mg injections) | 300 mg every 4 weeks (Q4W)
30 to less than 60 kg | 400 mg (two 200 mg injections) | 200 mg every other week (Q2W)
60 kg or more | 600 mg (two 300 mg injections) | 300 mg every other week (Q2W)
For a 30 kg child with severe atopic dermatitis, the recommended dose of Dupixent (dupilumab) is:
- Initial Loading Dose: 600 mg (two 300 mg injections)
- Subsequent Dosage: 300 mg every 4 weeks (Q4W) 1
From the Research
For a child weighing 30 kg with severe atopic dermatitis, the recommended dose of Dupixent (dupilumab) is 200 mg given every 2 weeks. The medication is administered as a subcutaneous injection, typically in the thigh, abdomen, or upper arm.
Key Points to Consider:
- For children in this weight range (≥30 kg), Dupixent comes in pre-filled syringes or pens containing 200 mg of the medication.
- Before starting treatment, baseline laboratory tests may be considered, though they are not mandatory.
- The child should continue using moisturizers daily as part of their skin care routine, and topical corticosteroids or calcineurin inhibitors can be used as needed for flare-ups.
- Dupixent works by blocking interleukin-4 and interleukin-13 signaling, which are key drivers of type 2 inflammation in atopic dermatitis.
- Common side effects include injection site reactions and conjunctivitis.
- Parents should be instructed on proper injection technique if they will be administering the medication at home.
- Improvement in symptoms is typically seen within 2-4 weeks, but the full effect may take up to 16 weeks. This recommendation is based on the most recent and highest quality study available, which demonstrated the efficacy and safety of dupilumab in children with severe atopic dermatitis 2.