From the Research
The most effective topical treatment for seborrheic keratosis is a mixture of antioxidants, keratolytic, and hydrating agents, as evidenced by a recent pilot study published in 2025 1. This treatment approach has shown promise in improving the appearance of seborrheic keratoses. The study found that a 5-to-17-day course of a topical mixture composed of antioxidant, keratolytic, and hydrating agents, followed by scooping of softened SK, improved the appearance of 5 SKs.
Some key points to consider when treating seborrheic keratosis include:
- The use of over-the-counter options like salicylic acid, lactic acid, or urea-containing products can help gradually remove these benign skin growths.
- Professional treatments, such as 40% hydrogen peroxide solution (Eskata), can be effective in oxidizing and breaking down abnormal skin cells, as shown in studies published in 2018 2 and 2021 3.
- Retinoids like tretinoin or adapalene can also be effective for smaller lesions by increasing cell turnover.
- Cryotherapy with liquid nitrogen is a common procedure used in dermatology offices, but it is not a topical treatment.
It's essential to note that seborrheic keratoses are benign growths, and treatment is primarily for cosmetic reasons or if the lesions become irritated. Before attempting self-treatment, having a dermatologist confirm the diagnosis is recommended, as some skin cancers can resemble seborrheic keratosis.
In terms of specific treatment options, a study published in 2021 compared the efficacy and safety of 30% hydrogen peroxide with 50% trichloroacetic acid in seborrheic keratosis and found that hydrogen peroxide produced greater clearance of seborrheic keratosis 4. However, the most recent and highest-quality study published in 2025 1 suggests that a topical mixture of antioxidants, keratolytic, and hydrating agents may be a more effective treatment option.
Overall, the choice of treatment for seborrheic keratosis depends on various factors, including the size and location of the lesions, as well as the patient's individual needs and preferences. A topical mixture of antioxidants, keratolytic, and hydrating agents, as described in the 2025 study 1, is a promising treatment option that warrants further investigation.