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Last updated: July 14, 2025View editorial policy

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Differential Diagnosis for Rash

  • Single most likely diagnosis
    • Eczema (Atopic Dermatitis): This is often the most common cause of rash, especially in children and individuals with a history of allergies or asthma. It presents with itchy, inflamed skin that can appear anywhere on the body.
  • Other Likely diagnoses
    • Contact Dermatitis: This occurs when the skin comes into contact with an irritant or allergen, leading to a rash. It's common and can be caused by a variety of substances, including soaps, detergents, or certain plants.
    • Psoriasis: An autoimmune condition characterized by thick, scaly, red patches on the skin. It can appear anywhere but is most common on the elbows, knees, and scalp.
    • Allergic Reaction: Can be caused by a wide range of allergens, including foods, medications, or insect bites, leading to hives or a more generalized rash.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Meningococcemia: A severe infection caused by Neisseria meningitidis, which can present with a rash (petechiae or purpura) and is life-threatening if not treated promptly.
    • Rocky Mountain Spotted Fever: A tick-borne illness that can cause a rash, fever, and headache, and can be fatal if not treated with antibiotics.
    • Toxic Epidermal Necrolysis (TEN) or Stevens-Johnson Syndrome (SJS): Severe skin conditions usually triggered by medications, leading to widespread skin necrosis and detachment. They are medical emergencies.
  • Rare diagnoses
    • Pemphigus: A group of autoimmune diseases that cause blistering of the skin and mucous membranes. It's rare but can be life-threatening if not treated.
    • Kawasaki Disease: An illness that mainly affects children, causing fever, rash, and swelling of the hands and feet. It can lead to serious heart problems if not treated.
    • Lupus: A chronic autoimmune disease that can affect various parts of the body, including the skin, joints, and organs. It can cause a variety of rashes, among other symptoms.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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