From the Research
Restylane Defyne should be injected into the deep dermis or subcutaneous tissue layers, depending on the treatment area and desired outcome, for the correction of moderate to severe facial wrinkles and folds, with deep injection providing slight midface lifting and improved facial aesthetics, as shown in a 52-week, prospective, randomized, double-blinded study 1. The indication for Restylane Defyne injections is for the correction of moderate to severe facial wrinkles and folds, and it can be injected into the subdermal, deep dermal, and subcutaneous layers.
- The typical injection depth ranges from 2.5mm to 5mm below the skin surface.
- Proper placement is crucial for optimal results and safety; too superficial placement can cause visible lumps or a bluish discoloration (Tyndall effect), while too deep placement may reduce effectiveness.
- Restylane Defyne contains XpresHAn Technology™ which provides flexibility and natural movement in dynamic facial areas.
- Results typically last 12-18 months, with potential side effects including temporary swelling, bruising, and tenderness at injection sites.
- The procedure should only be performed by qualified healthcare providers with specific training in facial anatomy and injection techniques. The most recent and highest quality study 1 supports the use of Restylane Defyne for the correction of moderate to severe facial wrinkles and folds, with deep injection providing better results in terms of midface lifting and facial aesthetics.
- This study showed that Restylane Defyne had a more prolonged effect compared to another hyaluronic acid filler, with significant improvement in wrinkle severity and Global Aesthetic Improvement Scale scores.
- The study also found that deep injection provided slight midface lifting and improved facial aesthetics, with high patient satisfaction and a favorable safety profile. Other studies 2, 3, 4, 5 also support the use of Restylane Defyne for facial rejuvenation, but they are either older or of lower quality, and do not provide as strong evidence as the most recent study 1.