Administration Guidelines for Sermorelin Glycine Troche
Sermorelin glycine troches should be placed under the tongue and allowed to dissolve completely, typically administered once daily at bedtime.
What is Sermorelin?
Sermorelin is a 29-amino acid analogue of human growth hormone-releasing hormone (GHRH) that stimulates the pituitary gland to produce and release growth hormone. It is the shortest synthetic peptide that maintains the full biological activity of natural GHRH 1.
Administration Instructions
Proper Troche Administration Technique:
- Place the troche under the tongue (sublingual administration)
- Allow it to dissolve completely
- Do not swallow the troche whole
- Do not eat, drink, or smoke while the troche is dissolving
- Avoid swallowing saliva until the troche has completely dissolved
Timing and Dosage:
- Administer once daily
- Best taken at bedtime to mimic natural growth hormone release patterns
- Standard dosage is typically 30 μg/kg bodyweight 1
Clinical Considerations
Expected Effects:
- Stimulates endogenous growth hormone secretion from the anterior pituitary
- Effects may take several months to become noticeable
- Regular monitoring of response is recommended
Duration of Treatment:
- Long-term effects on adult height and other outcomes require continued monitoring
- Limited data suggest effects can be maintained for up to 36 months of continued treatment 1
Common Side Effects
- Transient facial flushing
- Pain or irritation at administration site (in this case, under the tongue)
- These side effects are typically mild and transient 1
Important Precautions
- Sermorelin is not recommended as first-line therapy for growth hormone deficiency, as direct growth hormone therapy has shown superior results in comparative studies 2
- The effect on final adult height is not yet determined with long-term treatment 1
- Sermorelin does not cross the placenta, which is an important consideration for pregnant women 3
Monitoring
- No specific routine monitoring tests are required for the medication itself
- Clinical response should be evaluated periodically
- For patients using sermorelin for growth hormone deficiency, height velocity should be monitored
Storage Instructions
- Keep troches in their original container
- Store at room temperature away from moisture and heat
- Keep out of reach of children
By following these administration guidelines, patients can maximize the potential benefits of sermorelin glycine troches while minimizing potential side effects.