What is the cause of unilateral upper back muscle pain?

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Last updated: February 8, 2025View editorial policy

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Differential Diagnosis for Unilateral Upper Back Muscular Pain

  • Single most likely diagnosis
    • Muscular strain: This is the most common cause of unilateral upper back pain, often resulting from overuse, poor posture, or direct trauma to the muscles.
  • Other Likely diagnoses
    • Thoracic outlet syndrome: Compression of the nerves and/or blood vessels between the clavicle and first rib can cause pain in the upper back, often unilateral.
    • Scoliosis: Abnormal curvature of the spine can lead to uneven muscle strain, resulting in unilateral upper back pain.
    • Rib fracture: A fracture of one of the ribs can cause severe, localized pain in the upper back.
    • Myofascial pain syndrome: Irritation of the muscles and their surrounding connective tissue can cause pain, often unilateral, in the upper back.
  • Do Not Miss diagnoses
    • Pulmonary embolism: Although less common, a pulmonary embolism can cause sudden, severe chest pain that may radiate to the upper back, and is a medical emergency.
    • Pneumothorax: A collapsed lung can cause sudden, severe chest pain that may radiate to the upper back, and requires immediate medical attention.
    • Spinal infection (e.g., osteomyelitis, discitis): Infections of the spine can cause severe, localized pain, and if left untreated, can lead to serious complications.
    • Pancoast tumor: A type of lung cancer that can cause shoulder and upper back pain due to compression of nearby nerves.
  • Rare diagnoses
    • Multiple myeloma: A type of blood cancer that can cause bone pain, including in the upper back.
    • Osteoporotic compression fracture: A fracture of a vertebra due to osteoporosis can cause sudden, severe back pain.
    • Spinal cord tumor: A tumor in the spinal cord can cause pain, numbness, and weakness, and requires prompt medical attention.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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