Persistent Genital Arousal Disorder (PGAD): This condition is characterized by persistent, unwanted, and unrelenting genital arousal in the absence of any sexual desire or stimulation. It's a condition that can significantly affect quality of life and is more common in women, making it a likely diagnosis for uncontrolled orgasms.

Overactive Bladder: While primarily associated with urinary urgency and frequency, some women with overactive bladder may experience orgasmic symptoms due to the close anatomical relationship between the bladder and genital areas.
Vulvar Vestibulitis: A condition causing chronic pain and discomfort in the vulvar area, which might lead to involuntary orgasmic responses due to hypersensitivity.
Hormonal Imbalance: Changes in hormone levels, particularly estrogen, can affect sexual function and potentially lead to uncontrolled orgasms.
Certain Medications: Some medications, including antidepressants and blood pressure medications, can have sexual side effects, including increased orgasmic activity.

Spinal Cord Injury or Disease: Conditions affecting the spinal cord, such as multiple sclerosis, spinal cord injury, or tumors, can lead to uncontrolled sexual responses, including orgasms, due to the disruption of normal neurological pathways.
Epilepsy: Certain types of epilepsy, particularly those involving the temporal lobe, can cause sexual auras or uncontrolled orgasms as part of seizure activity.
Tumors: Rarely, tumors in the genital or pelvic area can cause uncontrolled orgasms by putting pressure on nerves or altering normal anatomical and physiological functions.

Narcolepsy: Although primarily known for causing excessive daytime sleepiness, narcolepsy can also lead to cataplexy, which in rare cases might manifest as orgasmic episodes.
Kluver-Bucy Syndrome: A rare condition usually resulting from bilateral damage to the amygdalae, which can lead to hypersexuality among other symptoms.
Other Neurological Conditions: Conditions like Parkinson's disease, treated with certain medications, can lead to hypersexuality as a side effect, though uncontrolled orgasms would be an unusual presentation.