Persistent Genital Arousal Disorder (PGAD): This condition is characterized by persistent, unwanted, and unrelenting genital arousal in the absence of any sexual desire or stimulation. It's more common in women but can occur in men as well. The age of onset can vary, and it might be triggered by various factors including hormonal changes, certain medications, or psychological factors.

Overactive Bladder or Urinary Incontinence: Conditions that can lead to involuntary loss of urine, sometimes mistaken for or contributing to uncontrolled orgasms due to the proximity of the urinary and genital systems.
Neurological Conditions (e.g., Multiple Sclerosis, Spinal Cord Injury): Certain neurological conditions can affect the nerves controlling sexual function, leading to uncontrolled or inappropriate sexual responses.
Medication Side Effects: Some medications, particularly those affecting the central nervous system or used to treat depression and other psychiatric conditions, can have sexual side effects including increased arousal or spontaneous orgasms.
Hormonal Imbalances: Changes in hormone levels, especially testosterone and estrogen, can influence sexual function and potentially lead to uncontrolled orgasms.

Tumors or Cysts (e.g., Tarlov Cysts, Spinal Tumors): Although rare, tumors or cysts pressing on the spinal cord or nerves can cause a variety of sexual dysfunctions, including uncontrolled orgasms. Missing these diagnoses could lead to significant morbidity or mortality if left untreated.
Infections (e.g., Neurosyphilis, Spinal Abscess): Infections affecting the central nervous system can have a wide range of symptoms, including sexual dysfunction. These conditions require prompt diagnosis and treatment to prevent serious complications.
Vascular Conditions (e.g., Atherosclerosis, Arteriovenous Malformations): Certain vascular conditions can affect blood flow to the genital area or press on nerves, potentially leading to sexual dysfunction.

Epilepsy (Specifically, Orgasmic Epilepsy): A rare condition where seizures are triggered by or result in orgasm.
Narcolepsy: Although primarily known for causing excessive daytime sleepiness, narcolepsy can also lead to cataplexy, which in rare cases might be triggered by orgasm.
Other Rare Neurological Disorders: Conditions like restless genital syndrome or certain types of dystonia can also present with symptoms of uncontrolled orgasms, though these are exceedingly rare.