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Differential Diagnosis for Ulcerating Papular One-Sided Rash in a 3-Year-Old

Single Most Likely Diagnosis

  • Impetigo: A common, highly contagious skin infection in children, often presenting with ulcerating papules, especially if the rash is unilateral. It's caused by Staphylococcus aureus or Streptococcus pyogenes.

Other Likely Diagnoses

  • Eczema (Atopic Dermatitis): Can sometimes present with ulcerations, especially if scratched, and may appear unilateral, though it's typically bilateral. It's a chronic condition characterized by dry, itchy skin.
  • Insect Bites: Could cause a unilateral rash if the child was exposed to bites on one side of the body. The bites can become ulcerated if scratched.
  • Contact Dermatitis: An allergic reaction or irritation from something that came into contact with the skin, which could present unilaterally and cause ulcerating papules.

Do Not Miss Diagnoses

  • Child Abuse: It's crucial to consider non-accidental injury, especially if the rash or ulcers have a pattern suggestive of inflicted trauma.
  • Staphylococcal Scalded Skin Syndrome (SSSS): Although more common in infants, SSSS can occur in toddlers and presents with widespread skin lesions that can start unilaterally, progressing to a more generalized rash.
  • Herpes Simplex Virus (HSV) Infection: Can cause localized, painful ulcers, and while less common in this presentation, it's a critical diagnosis not to miss due to potential for serious complications.

Rare Diagnoses

  • Bullous Pemphigoid: An autoimmune blistering disease that can rarely occur in children, presenting with large blisters that may ulcerate.
  • Epidermolysis Bullosa: A group of genetic conditions that result in fragile skin and blisters, which can ulcerate, often from minor trauma.
  • Cutaneous Leishmaniasis: Depending on the geographical location, this parasitic infection can cause skin ulcers, though it's uncommon in many areas and typically associated with travel history or endemic regions.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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