Differential Diagnosis for Ulcerating Papular One-Sided Rash in a 3-Year-Old
Single Most Likely Diagnosis
- Impetigo: A common, highly contagious skin infection in children, often presenting with ulcerating papules, especially if the rash is unilateral. It's caused by Staphylococcus aureus or Streptococcus pyogenes.
Other Likely Diagnoses
- Eczema (Atopic Dermatitis): Can sometimes present with ulcerations, especially if scratched, and may appear unilateral, though it's typically bilateral. It's a chronic condition characterized by dry, itchy skin.
- Insect Bites: Could cause a unilateral rash if the child was exposed to bites on one side of the body. The bites can become ulcerated if scratched.
- Contact Dermatitis: An allergic reaction or irritation from something that came into contact with the skin, which could present unilaterally and cause ulcerating papules.
Do Not Miss Diagnoses
- Child Abuse: It's crucial to consider non-accidental injury, especially if the rash or ulcers have a pattern suggestive of inflicted trauma.
- Staphylococcal Scalded Skin Syndrome (SSSS): Although more common in infants, SSSS can occur in toddlers and presents with widespread skin lesions that can start unilaterally, progressing to a more generalized rash.
- Herpes Simplex Virus (HSV) Infection: Can cause localized, painful ulcers, and while less common in this presentation, it's a critical diagnosis not to miss due to potential for serious complications.
Rare Diagnoses
- Bullous Pemphigoid: An autoimmune blistering disease that can rarely occur in children, presenting with large blisters that may ulcerate.
- Epidermolysis Bullosa: A group of genetic conditions that result in fragile skin and blisters, which can ulcerate, often from minor trauma.
- Cutaneous Leishmaniasis: Depending on the geographical location, this parasitic infection can cause skin ulcers, though it's uncommon in many areas and typically associated with travel history or endemic regions.