From the Research
Interaction between Dihydrocodeine and 5-Hydroxytryptophan (5-HTP)
There is no direct evidence in the provided studies to suggest an interaction between dihydrocodeine and 5-Hydroxytryptophan (5-HTP).
Available Information on 5-HTP
- 5-HTP is a precursor to serotonin and is used to treat depression and other serotonin-related diseases 1, 2, 3.
- The efficacy of 5-HTP in treating depression is still uncertain due to limited high-quality studies 1.
- 5-HTP can be contraindicated for depression in some patients, and its use should be approached with caution 2.
- The physiological effects of 5-HTP have been studied in both animal and human clinical trials, and it has been found to play a role in various neurological and metabolic diseases 3.
Pharmacology of 5-HTP
- 5-HTP can be administered with carbidopa to increase its bioavailability and reduce peripheral side effects 4, 5.
- The pharmacokinetics of 5-HTP have been studied, and it has been found to exhibit dose-dependent increases in cortisol and prolactin concentrations 4, 5.
- The use of 5-HTP as a challenge test for the serotonergic system has been investigated, and it has been found to be effective but limited by side effects such as nausea and vomiting 4, 5.