What are the ICD-10 codes for testosterone, estradiol, and progesterone?

ICD-10 Codes for Testosterone, Estradiol, and Progesterone

The ICD-10 codes for testosterone, estradiol, and progesterone abnormalities are E29.1 for testicular hypofunction, E28.0 for estrogen excess, and E28.3 for primary ovarian failure, respectively.

Testosterone-Related ICD-10 Codes

Testosterone abnormalities are primarily coded under endocrine disorders:

• E29.1: Testicular hypofunction (includes hypogonadism and low testosterone)
• E29.8: Other testicular dysfunction
• E29.9: Testicular dysfunction, unspecified
• E23.0: Hypopituitarism (when testosterone deficiency is due to pituitary issues)

Clinical Context for Testosterone Coding

Testosterone deficiency should be properly documented with appropriate laboratory testing before assigning these codes. According to AUA guidelines, patients should have both:

• Morning total testosterone levels below the reference range
• Symptoms consistent with testosterone deficiency 1

Estradiol-Related ICD-10 Codes

Estradiol abnormalities are coded under female reproductive endocrine disorders:

• E28.0: Estrogen excess
• E28.3: Primary ovarian failure (includes low estradiol due to ovarian failure)
• E28.8: Other ovarian dysfunction
• E28.9: Ovarian dysfunction, unspecified
• E89.40: Asymptomatic postprocedural ovarian failure
• E89.41: Symptomatic postprocedural ovarian failure

Clinical Context for Estradiol Coding

Estradiol levels are particularly important in monitoring:

• Menopausal status
• Premature ovarian insufficiency
• Hormone replacement therapy effectiveness 1

Progesterone-Related ICD-10 Codes

Progesterone abnormalities are typically coded under:

• E28.3: Primary ovarian failure (includes progesterone deficiency)
• E28.8: Other ovarian dysfunction (includes luteal phase defects)
• E28.9: Ovarian dysfunction, unspecified
• O09.A: Supervision of pregnancy with history of molar pregnancy (when monitoring progesterone)

Clinical Significance of Hormone Testing

Proper hormone testing is essential for accurate diagnosis. It's worth noting that direct immunoassay kits for estradiol and testosterone may have limitations in accuracy, particularly at low concentrations seen in postmenopausal women 2. Mass spectrometry methods are generally more reliable for precise measurements.

Common Pitfalls in Hormone Testing and Coding

1. Time of sampling matters: Testosterone should be measured in the morning when levels are highest 1

2. Assay limitations: Standard immunoassays may not accurately measure low levels of sex hormones 2

3. Coding specificity: Using general endocrine disorder codes rather than specific hormone abnormality codes can lead to reimbursement issues

4. Failure to document symptoms: Hormone abnormalities should be coded with corresponding clinical manifestations when present

5. Monitoring considerations: For patients on hormone therapy, different codes may apply for monitoring versus diagnosing deficiency states

Always ensure that appropriate laboratory testing confirms hormone abnormalities before assigning these diagnostic codes, as treatment decisions and insurance coverage often depend on proper documentation.