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Last updated: July 17, 2025View editorial policy

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Differential Diagnosis for Non-STD Vaginal Bumps

Single Most Likely Diagnosis

  • Vulvar cysts: These are common, benign lesions that can appear as bumps on the vulva. They are often filled with fluid or semi-solid material and can be caused by a blocked gland or duct.

Other Likely Diagnoses

  • Folliculitis: An inflammation of the hair follicles, which can cause bumps or pus-filled lesions on the vulva.
  • Vulvar acne: Similar to acne on other parts of the body, vulvar acne can cause bumps, pimples, or blackheads in the vulvar area.
  • Keratosis pilaris: A harmless condition that causes small, rough bumps on the skin, often on the vulva, thighs, or buttocks.
  • Vulvar dermatitis: An inflammation of the vulvar skin, which can cause bumps, redness, and itching.

Do Not Miss Diagnoses

  • Squamous cell carcinoma: A type of skin cancer that can appear as a bump or lesion on the vulva. Although rare, it is crucial to rule out this diagnosis due to its potential severity.
  • Melanoma: A type of skin cancer that can appear as a new or changing mole on the vulva. Early detection is critical for effective treatment.
  • Vulvar intraepithelial neoplasia (VIN): A precancerous condition that can cause bumps or lesions on the vulva. If left untreated, it can progress to invasive cancer.

Rare Diagnoses

  • Vulvar syringoma: A rare, benign tumor that can cause small, bumps or lesions on the vulva.
  • Vulvar neurofibromas: Rare, benign tumors that can cause bumps or lesions on the vulva, often associated with neurofibromatosis type 1.
  • Vulvar lymphangioma: A rare, benign condition that can cause bumps or lesions on the vulva, often due to abnormal lymphatic vessel development.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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