Differential Diagnosis for One Side of Nose Pain

• Single most likely diagnosis
  • Sinusitis: This is the most likely diagnosis due to the common occurrence of sinus infections which can cause pain on one side of the nose. The pain is often accompanied by other symptoms such as nasal congestion, discharge, and headache.
• Other Likely diagnoses
  • Deviated septum: A deviated septum can cause pain on one side of the nose due to uneven airflow and pressure. This condition may also lead to nasal congestion and difficulty breathing.
  • Nasal polyps: Polyps in the nasal passage can cause pain, congestion, and loss of smell. They often occur on one side of the nose and can be associated with allergies or asthma.
  • Trauma: A recent injury to the nose can cause pain on one side, which may be accompanied by swelling, bruising, and bleeding.
• Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
  • Malignant tumor: Although rare, a tumor in the nasal cavity or sinuses can cause pain on one side of the nose. It is crucial to rule out this possibility, especially in older adults or those with a history of cancer.
  • Cavernous sinus thrombosis: This is a rare but life-threatening condition that can cause pain on one side of the nose, along with other symptoms such as fever, headache, and vision changes.
  • Orbital cellulitis: An infection of the tissues surrounding the eye can cause pain on one side of the nose, as well as swelling, redness, and vision changes.
• Rare diagnoses
  • Trigeminal neuralgia: This condition causes sudden, severe pain in the face, including the nose, often triggered by touch or movement. It is relatively rare and usually affects older adults.
  • Sphenoid sinusitis: Infection of the sphenoid sinus, which is located behind the nasal cavity, can cause pain on one side of the nose, as well as headache and vision changes. This condition is rare due to the sphenoid sinus's location and relatively small size.