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Last updated: July 20, 2025View editorial policy

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Differential Diagnosis for Large Nose Rosacea

  • Single most likely diagnosis
    • Rhinophyma: This is the most likely diagnosis due to the characteristic large, red, and bulbous nose appearance, which is a subtype of rosacea. It is more common in men and typically occurs after years of having rosacea.
  • Other Likely diagnoses
    • Acne: Although not typically causing a large nose, severe acne can lead to significant inflammation and scarring, potentially altering the nose's appearance.
    • Seborrheic dermatitis: This condition can cause redness and inflammation on the nose, but it usually doesn't result in the significant enlargement seen in rhinophyma.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Basal cell carcinoma or squamous cell carcinoma: Although less likely, these skin cancers can present with lesions on the nose and, if left untreated, can lead to significant morbidity and mortality.
    • Sarcoidosis: This systemic disease can cause skin lesions, including on the nose, and if not diagnosed, can lead to serious complications affecting multiple organ systems.
  • Rare diagnoses
    • Neurofibromatosis: This genetic disorder can cause tumors to grow on nerve tissue, potentially leading to a large nose appearance due to neurofibromas, but this is much rarer than rhinophyma.
    • Hemangioma: A benign tumor made up of blood vessels that can occur on the nose, potentially causing enlargement, but this is less common in adults and typically presents earlier in life.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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