Cost of Amitiza (Lubiprostone)
The monthly cost of Amitiza (lubiprostone) is approximately $946 based on the most recent evidence, making it a relatively expensive medication for chronic constipation treatment compared to some alternatives.
Cost Information
According to the available evidence, Amitiza has the following cost structure:
- Average cost per 30-day supply: $946 1
- This is comparable to but slightly lower than lubiprostone's competitor Linzess (linaclotide), which costs approximately $1,015 for a 30-day supply 1
Dosing and Cost Considerations
Amitiza is typically prescribed at different dosages depending on the condition being treated:
- For chronic idiopathic constipation: 24 μg twice daily 2
- For irritable bowel syndrome with constipation (women only): 8 μg twice daily 2
- For opioid-induced constipation: 24 μg twice daily 2
Insurance Coverage and Payment Options
It's important to note that the actual out-of-pocket cost to patients may vary significantly based on:
- Insurance coverage
- Pharmacy benefit structure
- Whether the medication is covered under medical or pharmacy benefits
- Availability of patient assistance programs
Cost Comparison with Other Medications
When comparing Amitiza to other medications used for similar conditions:
- Generic medications for constipation are typically much less expensive
- For example, generic laxatives like polyethylene glycol (PEG) cost significantly less
- Other prescription medications for chronic constipation may have different price points as shown in medication cost tables 3
Potential Cost-Saving Strategies
Patients concerned about the cost of Amitiza may consider:
- Checking if their insurance covers this medication
- Asking their healthcare provider about pharmaceutical manufacturer prescription assistance programs, though these require administrative time and resources 4
- Discussing with their healthcare provider whether a less expensive alternative might be appropriate for their condition
Clinical Value Consideration
Despite its cost, Amitiza has demonstrated effectiveness in:
- Increasing spontaneous bowel movement frequency 5
- Improving stool consistency 5
- Reducing straining and abdominal bloating 5
- Providing relief within 24 hours after the first dose in 60% of patients (vs. 41.5% for placebo) 5
The cost of Amitiza should be weighed against its clinical benefits and the impact of untreated chronic constipation on quality of life when making treatment decisions.