Dosing Schedule for Augmentin (Amoxicillin-Clavulanate)
Augmentin (amoxicillin-clavulanate) should be taken every 8 hours or every 12 hours depending on the specific formulation prescribed, with each dose taken with food to reduce gastrointestinal upset. 1
Dosing Intervals
The appropriate dosing interval for Augmentin depends on the specific formulation:
Every 8 hours (three times daily):
- Standard formulation (250/125 mg, 500/125 mg)
- Used for most common infections
- Example: 8am, 4pm, 12am
Every 12 hours (twice daily):
- Extended-release or high-dose formulations (875/125 mg)
- Example: 8am, 8pm
Important Administration Guidelines
- Take with food: Each dose should be taken with a meal or snack to minimize stomach upset 1
- Complete the full course: Even if you feel better before finishing the prescription, take all doses as directed to prevent bacterial resistance 1
- Space doses evenly: Try to maintain consistent intervals between doses for optimal antibiotic levels in the bloodstream
Clinical Evidence
Multiple studies support the effectiveness of Augmentin when administered at these intervals:
- Research shows that amoxicillin-clavulanate administered every 8 hours achieves effective blood and tissue concentrations for treating respiratory infections 2
- For higher-dose formulations (875/125 mg), the 12-hour interval maintains adequate drug levels while improving patient convenience 1
Special Considerations
- Missed doses: If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. Never take a double dose to make up for a missed one.
- Storage: Keep suspension formulations refrigerated and shake well before each use 1
- Side effects: Common side effects include diarrhea, nausea, and skin rash. Contact your doctor if you experience severe diarrhea, especially if it contains blood or mucus 1
Common Pitfalls to Avoid
- Taking on an empty stomach: This increases the risk of gastrointestinal side effects
- Irregular timing: Inconsistent dosing can lead to suboptimal antibiotic levels and treatment failure
- Stopping early: Discontinuing treatment prematurely can lead to recurrent infection and antibiotic resistance
- Not refrigerating suspension: Liquid formulations require refrigeration to maintain potency
Remember that proper adherence to the prescribed dosing schedule is essential for effective treatment and to prevent the development of antibiotic resistance.