Is it safe to donate plasma while taking Synthroid (levothyroxine)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: March 3, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Research

Yes, it is generally safe to donate plasma while taking Synthroid (levothyroxine). Synthroid is a medication used to treat hypothyroidism by replacing the thyroid hormone your body is unable to produce. Since Synthroid is simply replacing a hormone that would normally be present in your body, it typically doesn't affect your eligibility to donate plasma. However, you should always inform the donation center staff about all medications you're taking, including Synthroid, during the pre-donation screening. The important consideration is that your thyroid condition should be stable and well-controlled with the medication. If you have recently started Synthroid or had your dosage adjusted, it might be best to wait until your thyroid levels have stabilized before donating. This is because your body needs time to adjust to the medication, and donating plasma during this adjustment period could potentially affect how you feel. Most plasma donation centers will accept donors on Synthroid as long as the underlying thyroid condition is under control and you're feeling well.

Key Considerations

  • Inform the donation center staff about all medications, including Synthroid, during the pre-donation screening 1
  • Ensure your thyroid condition is stable and well-controlled with the medication
  • Wait until your thyroid levels have stabilized before donating if you have recently started Synthroid or had your dosage adjusted
  • Donating plasma during the adjustment period could potentially affect how you feel

Donor Safety

The safety of plasma donation has been studied in several reviews, including a systematic review of the impact of plasmapheresis frequency on cardiovascular health, protein depletion, and adverse events in healthy plasma donors 2. Another scoping review and evidence gap map identified the existing evidence on adverse events and other health effects in plasmapheresis donors 1. These studies suggest that plasma donation is generally safe, but high-quality evidence is needed to facilitate practice change that is safe and sustainable.

Medication and Donation

There is no direct evidence to suggest that taking Synthroid affects the safety of plasma donation. However, it is essential to inform the donation center staff about all medications you're taking, including Synthroid, during the pre-donation screening. This ensures that any potential risks or interactions are identified and managed.

Quality of Life

Donating plasma while taking Synthroid should not significantly impact your quality of life, as long as your thyroid condition is stable and well-controlled with the medication. However, it is crucial to follow the donation center's guidelines and recommendations to ensure your safety and well-being.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.